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Biopolymers. 1995;37(4):281-92.

The importance of extended conformations and, in particular, the PII conformation for the molecular recognition of peptides.

Author information

1
Department of Chemistry, Birkbeck College, University of London, United Kingdom.

Abstract

Crystallographic, isotopic labeling nmr and transferred nuclear Overhauser effect studies have highlighted the extended conformation as a very important element of secondary structure at the binding site of many peptide/protein complexes including peptide inhibitors-enzymes, B-cell epitopes-antibodies, and T-cell epitopes-major histocompatibility complex (MHC) of class I and II complexes. This paper discusses the peptide ligand conformation consequences of these findings particularly in view of the identification of the PII conformation (left-handed extended polyproline II) in free solution.

PMID:
7540055
DOI:
10.1002/bip.360370406
[Indexed for MEDLINE]

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