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J Neurochem. 1995 Jun;64(6):2465-72.

Galectin-3, a beta-galactoside-binding animal lectin, binds to neural recognition molecules.

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Department of Neurobiology, Swiss Federal Institute of Technology, Z├╝rich.


In this study, we have investigated the ability of galectin-3, a beta-galactoside-binding animal lectin, to interact in vitro with different neural tissue-derived glycoproteins involved in cell-cell and cell-substrate adhesion. Galectin-3 interacted to varying degrees with the cell recognition molecules L1, the myelin-associated glycoprotein, and the neural cell adhesion molecule and the extracellular matrix molecules tenascin-C and tenascin-R but not with collagen type I. Binding of galectin-3 to the different glycoproteins tested was carbohydrate dependent and could be specifically inhibited by the addition of lactose and, to a lesser extent, galactose.

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