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Cancer Lett. 1995 May 4;91(1):145-9.

Alteration of expression in integrin beta 1-subunit correlates with invasion and metastasis in colorectal cancer.

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Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.


We have investigated the expression of the integrin beta 1 subunit in 51 colorectal cancer tissues using immunoblotting and have determined the relationship between expression and clinical stage. In comparison with normal mucosa the pre-beta-subunit (the precursor of beta 1-subunit) was increased in 15 cases and decreased in two cases, and expression of the beta 1-subunit was decreased in two cases. These alterations of expression of the beta 1-subunit were significantly correlated with lymph node metastasis and depth of invasion (P < 0.01). These results suggest that integrin plays an important role in the invasion and metastasis of colorectal cancer.

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