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Eur J Immunol. 1995 Apr;25(4):1125-8.

Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction.

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University of Montreal, Notre-Dame Hospital Research Center, Quebec, Canada.


Previous studies on the production of interleukin-12 (IL-12) have shown that it is released, together with other proinflammatory cytokines, shortly after exposure of phagocytic cells to a variety of pathogens. We here report that IL-12 is also released during the recall response to soluble antigen (Ag) devoid of intrinsic adjuvant activity. We show that activated T cells induce the production of IL-12 by monocytes via a mechanism involving the interaction of T cell-associated CD40 ligand with CD40 on monocytes. The data suggest that Ag presentation on monocytes favors the persistence of type 1 responses.

[Indexed for MEDLINE]

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