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Biochem Biophys Res Commun. 1995 Apr 26;209(3):989-95.

Further characterization of the 5'-flanking region of the rat lactase-phlorizin hydrolase gene.

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Division of Pediatric Gastroenterology and Nutrition, New England Medical Center, Tufts University School of Medicine, Boston, MA.


The lactase-phlorizin hydrolase gene is widely used as a marker of intestinal differentiation. Recent evidence demonstrating that transcription plays a major role in the regulation of this gene suggests that study of the 5'-flanking region will allow an understanding of how the expression of this gene is controlled. However, sequence, restriction, and primer extension analysis of a rat genomic clone has revealed that previously published data are incomplete. In the present study, we used a directed sequencing strategy to carefully analyze this region. Our expanded analysis of the 5'-flanking region of the lactase-phlorizin hydrolase gene should facilitate future studies of its structure and function.

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