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Trends Microbiol. 1995 Feb;3(2):75-8.

Regulation of the interferon-induced PKR: can viruses cope?

Author information

1
Dept of Microbiology, School of Medicine, University of Washington, Seattle 98195, USA.

Abstract

Viruses that fail to block the lethal effects of the double-stranded-RNA-activated protein kinase (PKR) may be doomed; why do so many viruses go to so much trouble to downregulate this interferon-induced protein kinase? PKR may regulate cell growth and proliferation in uninfected cells, suggesting that it also participates in the antiproliferative arm of the interferon response.

PMID:
7537157
DOI:
10.1016/s0966-842x(00)88880-0
[Indexed for MEDLINE]

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