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Cancer Surv. 1995;22:51-62.

Recognition of viral antigens at the cell surface.

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Institute of Molecular Medicine, John Radcliffe Hospital, Oxford.


There is now a very good understanding of the way in which epitope peptides are generated from virus proteins and how the peptides bind to the class I MHC molecules. This gives a framework in which to analyse the potentially protective cytotoxic T lymphocyte response in human immunodeficiency virus infection. A detailed understanding of the specificity of the responding T cells, the clonality of these T cells and the effects of virus variation on the CTL gives a possible explanation for the ultimate failure of the CTL response to control this virus infection.

[Indexed for MEDLINE]

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