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Curr Opin Immunol. 1994 Dec;6(6):907-12.

TCR V gene usage in autoimmunity.

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San Diego Regional Cancer Center.


With the use of polymerase chain reaction technology, investigators now have the ability to assess, in a comprehensive and rapid manner, the entire repertoire of T cell antigen receptors expressed by pathogenic cells present in virtually any disease site. A summary of studies of T cell receptor variable gene usage suggests that preferential expression can be identified most reproducibly when cells are isolated directly from pathogenic lesions. This provides a framework for future investigations in other autoimmune settings.

[Indexed for MEDLINE]

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