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Dev Neurosci. 1994;16(3-4):207-11.

Is p75NGFR involved in developmental neural cell death?

Author information

1
University of California, Los Angeles 90024-1769.

Abstract

The tumor necrosis factor receptor superfamily includes twelve members, at least two of which--tumor necrosis factor receptor I and FAS/Apo-1--induce cell death following ligand binding. This review summarizes data suggesting that two other members of the family--p75NGFR and CD40--achieve a similar effect in the inverse fashion; they induce apoptosis constitutively when unbound by their respective ligands, with the induction of apoptosis being inhibited by the binding of their respective ligands. The potential roles that such receptors may play in development and pathological processes are discussed.

PMID:
7535682
DOI:
10.1159/000112108
[Indexed for MEDLINE]

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