[Coincidence of hepatic angiosarcoma and insulin-resistance diabetes mellitus with high-dose intraperitoneal insulin therapy]

Verh Dtsch Ges Pathol. 1994:78:285-7.
[Article in German]

Abstract

Angiosarcoma of the liver was diagnosed at autopsy in a 50 year old female with insulin-resistant diabetes mellitus. Over the course of 27 years, the patient received 27 l of Insulin-preparations applied subcutaneously and by an intraperitoneal pump-system. The preparations contained 20 g phenol. Known carcinogens for angiosarcoma of the liver-thorotrast, monovinylchloride or arsenic-were excluded. Phenol is a well known carcinogen of the skin and its tumor-promoting potential has been demonstrated in vitro. We suggest phenol as a potential aetiologic factor for angiosarcoma of the liver.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Autopsy
  • Diabetes Complications*
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / pathology
  • Female
  • Hemangiosarcoma / complications
  • Hemangiosarcoma / pathology*
  • Humans
  • Injections, Subcutaneous
  • Insulin / administration & dosage
  • Insulin / therapeutic use
  • Insulin Infusion Systems*
  • Insulin Resistance*
  • Liver Neoplasms / complications
  • Liver Neoplasms / pathology*
  • Middle Aged
  • Retrospective Studies

Substances

  • Insulin