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FEBS Lett. 1995 Mar 6;360(3):291-3.

Up-regulation of nitric oxide synthase by estradiol in human aortic endothelial cells.

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Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.


We have examined the effects of sex hormones on calcium-dependent NO production and protein levels of NO synthase in cultured human aortic endothelial cells, which were treated with various doses of 17 beta-estradiol and testosterone for 8-48 h. Treatment with 17 beta-estradiol enhanced calcium-dependent NO production, but testosterone had exerted no effect. Western blot using monoclonal anti-human endothelial NO synthase antibody clarified that increased NO production by 17 beta-estradiol treatment was accompanied by increased NO synthase protein. Our results provide evidence that human endothelial NO synthase can be regulated by estrogens.

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