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Immunity. 1994 Aug;1(5):415-21.

A negative regulatory function of B7 revealed in B7-1 transgenic mice.

Author information

1
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.

Abstract

To analyze the functions of T cell costimulators in vivo, we have constructed a transgenic mouse strain that constitutively expresses murine B7-1 on mature B cells. Antibody responses to T-dependent hapten-protein conjugates and serum immunoglobulin levels are markedly depressed in B7-1 transgenic mice. This immune deficiency is not due to an intrinsic B cell defect, as antibody responses to T-independent hapten conjugates are normal. Furthermore, treatment with anti-B7-1 restores the capacity of transgenic mice to respond to hapten-protein conjugates, demonstrating that the deficient antibody responses are directly attributable to the expression of B7-1. These results suggest that the temporally regulated expression of costimulators such as B7-1 may contribute to either initiation or down-regulation (feedback inhibition) of T-dependent immune responses in vivo, and that the inhibitory function is dominant in transgenic mice that constitutively express high levels of this costimulator.

PMID:
7533646
DOI:
10.1016/1074-7613(94)90072-8
[Indexed for MEDLINE]

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