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Mutat Res. 1995 Feb;326(2):165-70.

Chromosomal damages by ethanol and acetaldehyde in Saccharomyces cerevisiae as studied by pulsed field gel electrophoresis.

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Institut für Biochemie und Molekularbiologie, Freie Universität Berlin, Germany.


We report on the effect of ethanol and acetaldehyde on yeast chromosomal DNA and on isolated DNA. Ethanol induced DNA single-strand breaks in repair deficient but not in repair proficient Saccharomyces cerevisiae. Acetaldehyde has a deleterious effect on chromosomal DNA in cells as well as on isolated DNA. The results presented support earlier data to show that ethanol is mutagenic via its first metabolite, acetaldehyde.

[Indexed for MEDLINE]

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