Fas antigen mRNA induction in postischemic murine brain

Brain Res. 1994 Sep 19;657(1-2):342-6. doi: 10.1016/0006-8993(94)90989-x.

Abstract

Fas antigen mRNA induction in the brain was examined using a transient global cerebral ischemia model in BALB/C mice. Northern blot analysis revealed little Fas antigen mRNA expression in the brains of sham-operated mice. A marked induction of Fas mRNA expression was detected in the brains of mice 6 h after 30 min of cerebral ischemia. These results suggest a possible apoptotic mechanism for cell death, mediated by the Fas antigen, in postischemic brain.

MeSH terms

  • Animals
  • Antigens, Surface / genetics*
  • Apoptosis / immunology*
  • Base Sequence
  • Disease Models, Animal
  • Ischemic Attack, Transient / immunology*
  • Male
  • Membrane Proteins / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • RNA, Messenger / biosynthesis*
  • Receptors, Cell Surface / immunology*
  • fas Receptor

Substances

  • Antigens, Surface
  • Membrane Proteins
  • RNA, Messenger
  • Receptors, Cell Surface
  • fas Receptor