Format

Send to

Choose Destination
See comment in PubMed Commons below
Nature. 1995 Jan 12;373(6510):117-22.

Viral dynamics in human immunodeficiency virus type 1 infection.

Author information

1
Division of Hematology/Oncology, University of Alabama at Birmingham 35294.

Abstract

The dynamics of HIV-1 replication in vivo are largely unknown yet they are critical to our understanding of disease pathogenesis. Experimental drugs that are potent inhibitors of viral replication can be used to show that the composite lifespan of plasma virus and virus-producing cells is remarkably short (half-life approximately 2 days). Almost complete replacement of wild-type virus in plasma by drug-resistant variants occurs after fourteen days, indicating that HIV-1 viraemia is sustained primarily by a dynamic process involving continuous rounds of de novo virus infection and replication and rapid cell turnover.

PMID:
7529365
DOI:
10.1038/373117a0
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center