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Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):611-8.

Crystal structure of the phosphotyrosine recognition domain SH2 of the Src oncogene product complexed with tyrosine-phosphorylated peptides.

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1
Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics, Saint-Louis, MO 63108.

Abstract

SH2 domains are protein modules specialized in recognizing phosphorylated tyrosine residues and their sequence contexts. The mechanism of phosphotyrosine recognition and context recognition was elucidated in a series of X-ray crystallographic experiments which are discussed below.

PMID:
7526915
[Indexed for MEDLINE]
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