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Neurosci Lett. 1994 Jun 20;174(2):157-9.

Argyrophilic thread-like structure in corticobasal degeneration and supranuclear palsy.

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Department of Neuropathology, Tokyo Institute of Psychiatry, Japan.


Massive argyrophilic thread-like structures (ATS) are observed in corticobasal degeneration and, in varied degrees, in some cases of progressive supranuclear palsy. Immunohistochemically, ATS has a full length of phosphorylated tau epitopes without ubiquitin. Gallyas- and immuno-electron microscopic observation revealed that ATS is a cytoskeletal abnormality occurred in both the inner and outer loop of the oligodendroglia. tau-Positive oligodendroglial tangles were distributed in the same region as ATS.

[Indexed for MEDLINE]

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