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Curr Opin Immunol. 1994 Aug;6(4):553-9.

Specificity and editing by apoptosis of virus-induced cytotoxic T lymphocytes.

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1
Department of Pathology, University of Massachusetts Medical Center, North Worcester 01655-0125.

Abstract

Recent studies have defined an immunological network by which the acute cytotoxic T-lymphocyte response to viral infection modulates or is modulated by the antigen load and by crossreactive memory T cells. Down regulation of the acute CTL response can be associated with either antigen-dependent or antigen-independent apoptosis, and the host enters a state of immune deficiency as these T cells become sensitized to apoptotic mechanisms.

PMID:
7524536
[Indexed for MEDLINE]
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