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Nucleic Acids Res. 1994 Sep 11;22(18):3681-4.

The single pseudouridine residue in Escherichia coli 16S RNA is located at position 516.

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Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110.


The number and location of pseudouridine residues in Escherichia coli 16S ribosomal RNA has been determined by a combination of direct and indirect methods. Only one residue was found, at position 516. This site is at the 5'-end of one of the three most highly conserved long sequences of this RNA molecule. A number of experimental findings have strongly implicated this loop in the fidelity of codon recognition by A-site bound tRNA. By virtue of its location, we suggest that psi 516 may also play a role in maintaining the fidelity of protein synthesis.

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