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Curr Opin Neurobiol. 1994 Jun;4(3):313-23.

Structural basis of ion channel permeation and selectivity.

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Beckman Center, Department of Molecular and Cellular Physiology, Stanford University Medical Center, California 94305.


There has been rapid progress in understanding the structural basis of ion selectivity and permeation in both ligand- and voltage-gated channels. Recognition of similarities in overall architecture within a channel class has led to an increasing focus on the specific molecular determinants that endow a channel with its own distinctive character. It has been possible in some cases to identify individual amino acids essential for ion selectivity.

[Indexed for MEDLINE]

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