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Nature. 1994 Sep 29;371(6496):389-95.

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

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1
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.

Abstract

Two different approaches to follow clones of B lymphocytes in a diverse preimmune repertoire reveal a new process for eliminating self-reactive cells in the periphery which depends on competition between cells with different specificities. A key feature of this censoring mechanism is the selective exclusion of self-antigen-binding B cells from the normal migration route into lymphoid follicles, resulting in their premature death. This is a striking example of homeostasis by cellular competition for limiting niches and may explain the paradoxical association between immunodeficiency and autoimmunity.

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PMID:
7522305
DOI:
10.1038/371389a0
[Indexed for MEDLINE]

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