Send to

Choose Destination
Nature. 1994 Sep 29;371(6496):389-95.

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

Author information

Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.


Two different approaches to follow clones of B lymphocytes in a diverse preimmune repertoire reveal a new process for eliminating self-reactive cells in the periphery which depends on competition between cells with different specificities. A key feature of this censoring mechanism is the selective exclusion of self-antigen-binding B cells from the normal migration route into lymphoid follicles, resulting in their premature death. This is a striking example of homeostasis by cellular competition for limiting niches and may explain the paradoxical association between immunodeficiency and autoimmunity.

Comment in

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center