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J Infect. 1994 May;28(3):279-85.

Hepatitis C virus infection in haemodialysis patients: a clinical and virological study.

Author information

1
Department of Medical Microbiology, University College London Medical School, U.K.

Abstract

A cohort of 66 patients on maintenance haemodialysis was examined for serological (anti-HCV) and virological (HCV-RNA) evidence of infection with hepatitis C virus (HCV). Nine (13.6%) were anti-HCV positive, all of whom had detectable HCV-RNA in their serum. Statistical analysis of various risk factors (including length of time on haemodialysis, history of blood transfusion, history of renal transplantation and of previous hepatitis B infection) showed that only the length of time on haemodialysis was significantly associated with the acquisition of HCV infection. Genotypic analysis showed that five patients were infected with genotype 1 and a further two were infected with genotype 4. The latter finding is of significance because strains of genotype 4 are extremely uncommon in Western Europe. These results demonstrate that intra-unit transmission of HCV-infection took place in a group of patients on maintenance haemodialysis.

PMID:
7522261
DOI:
10.1016/s0163-4453(94)91793-0
[Indexed for MEDLINE]

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