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FEBS Lett. 1994 Sep 12;351(3):311-3.

No requirement of reactive oxygen intermediates in Fas-mediated apoptosis.

Author information

1
Osaka Bioscience Institute, Japan.

Abstract

Fas is a cell surface molecule that mediates apoptosis, but the intracellular mechanisms leading to apoptosis are not well understood. It is known that diethylmaleate (DEM)-induced cell death can be blocked by substances with antioxidant activity. Here we have studied whether antioxidants have any effect on Fas-mediated apoptosis and show that they are not able to block Fas-mediated apoptosis. Therefore, it seems that reactive oxygen intermediate (ROI)-dependent and -independent mechanisms which lead to apoptosis do exist. Fas-mediated apoptosis probably proceeds via a ROI-independent pathway.

PMID:
7521851
DOI:
10.1016/0014-5793(94)00852-3
[Indexed for MEDLINE]
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