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J Bioenerg Biomembr. 1994 Jun;26(3):261-71.

Mitochondrial DNA variation in human populations and implications for detection of mitochondrial DNA mutations of pathological significance.

Author information

1
Department of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, Georgia 30322.

Abstract

Haplotype and phylogenetic analyses of "normal" mitochondrial DNAs (mtDNAs) have allowed a clarification of several controversial issues concerning the origin of humans, the time and colonization pattern of the various regions of the world, and the genetic relationships of modern human populations. More recently, the same type of analyses has also been applied to mtDNA disease studies. A review of these studies indicates that exhaustive screenings of "normal" mtDNA variation in all human populations associated with haplotype and phylogenetic analyses are essential if we are to understand the etiology of mitochondrial pathologies.

PMID:
7521328
DOI:
10.1007/bf00763098
[Indexed for MEDLINE]

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