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Methods Enzymol. 1994;235:657-67.

Assays of hemolytic toxins.

Author information

1
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison 53706.

Abstract

The ability to produce a cytolytic toxin contributes to the success of many organisms in a particular niche by such diverse means as lysis of a phagolysosomal membrane of the macrophage by hemolysin from the intracellular parasite Trypanosoma cruzi, disruption of leukocyte activity by the Escherichia coli hemolysin, and destruction of invading bacteria by hemolysin from the annelid Glycera dibranchiata. The relative contribution of erythrocyte lysis to survival of the cytolysin producer is still under investigation. Nevertheless, the hemolytic phenotype is both a powerful tool for identifying novel cytolysins and a convenient marker for studying cytolytic activity in established toxins.

PMID:
7520121
DOI:
10.1016/0076-6879(94)35179-1
[Indexed for MEDLINE]

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