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Trends Biotechnol. 1994 Jul;12(7):262-7.

Epitope discovery using peptide libraries displayed on phage.

Author information

1
Istituto di Ricerche di Biologia Molecolare P. Angeletti, Pomezia, Roma, Italy.

Abstract

Peptides displayed on phage, which mimic continuous and discontinuous epitopes, can be selected using purified antibodies or preparations of polyclonal serum. This review describes recent advances in this field, discusses the application of phage-display technology to the diagnosis of human diseases, and presents new ideas for the preparation of vaccines directed against specific epitopes on a pathogen.

PMID:
7519861
DOI:
10.1016/0167-7799(94)90137-6
[Indexed for MEDLINE]

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