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Biochem Biophys Res Commun. 1994 Jul 15;202(1):111-9.

Retrotransposition of the Drosophila LINE I element can induce deletion in the target DNA: a simple model also accounting for the variability of the normally observed target site duplications.

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Institut Gustave Roussy, CNRS URA147, Villejuif, France.


Retrotransposition of the Drosophila melanogaster LINE I element normally generates target site duplications of variable length, as classically observed for most LINE elements. Using an I element "marked" with an indicator gene for in vivo detection of transposition that we previously developed, we show that deletion in the target DNA can also take place, as a direct consequence of I element transposition. We propose a simple model accounting for the generation of both target site duplications of variable length and target DNA deletions, which relies upon template switching of the LINE-encoded reverse transcriptase between single-strand DNA at the target site and the LINE template.

[Indexed for MEDLINE]

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