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Science. 1994 Jul 22;265(5171):528-30.

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity.

Author information

1
Department of Pathology, University of Zürich, Switzerland.

Abstract

Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated. To determine the extent of their contribution to T cell-mediated cytotoxicity, a range of effector cells from normal control or perforin-deficient mice were tested against a panel of target cells with various levels of Fas expression. All cytotoxicity observed was due to either of these mechanisms, and no third mechanism was detected. Thus, the perforin- and Fas-based mechanisms may account for all T cell-mediated cytotoxicity in short-term in vitro assays.

PMID:
7518614
DOI:
10.1126/science.7518614
[Indexed for MEDLINE]

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