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Environ Health Perspect. 1993 Dec;101 Suppl 6:39-44.

Alpha 2u-globulin nephropathy: review of the cellular and molecular mechanisms involved and their implications for human risk assessment.

Author information

1
Department of Environmental Sciences, University of North Carolina at Chapel Hill 27599.

Abstract

This paper reviews what is known about the induction of alpha 2u-globulin nephropathy and carcinogenesis. This unique male-rat-specific disease is associated with exposure to an ever-increasing number of chemicals. The processes leading to nephropathy and renal cancer are among the best-understood mechanisms for nongenotoxic chemicals and strongly support that it is a male-rat-specific process that is not relevant for human risk assessment. Nevertheless, the data available for individual chemicals vary greatly. This necessitates a case-by-case analysis of the available data when determining the relevance for humans of this chemically induced renal disease in male rats.

PMID:
7517351
PMCID:
PMC1520017
DOI:
10.1289/ehp.93101s639
[Indexed for MEDLINE]
Free PMC Article

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