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Trends Neurosci. 1994 Mar;17(3):115-8.

Spontaneous Ca2+ spikes and waves in embryonic neurons: signaling systems for differentiation.

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Dept of Biology, University of California, San Diego, La Jolla 92093.


Many excitable cells are specialized to promote Ca2+ influx at early stages of development. This article focuses on spontaneous fluctuations of intracellular Ca2+ that are observed during this period. Removal of Ca2+ or suppression of influx alters subsequent differentiation. Thus these signals appear to regulate aspects of early maturation.

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