Format

Send to

Choose Destination
Curr Opin Immunol. 1994 Feb;6(1):125-30.

Recognition of endotoxin by cells leading to transmembrane signaling.

Author information

1
Department of Immunology, Scripps Research Institute, La Jolla, California 92037.

Abstract

Bacterial endotoxins act at picomolar to nanomolar concentrations to stimulate a wide variety of cell types including phagocytic and endothelial cells. The major elements identified to date that are crucial for recognition of endotoxin are lipopolysaccharide (LPS)-binding protein, membrane-bound CD14 and, most recently, soluble CD14. Recent results also indicate that membrane-bound CD14 is probably one part of a multi-component LPS receptor. An immediate consequence of engagement of this functional LPS receptor is protein tyrosine phosphorylation and initiation of the multiple intracellular events associated with LPS-induced cell activation.

PMID:
7513521
DOI:
10.1016/0952-7915(94)90043-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center