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Curr Opin Cell Biol. 1994 Feb;6(1):34-40.

Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease.

Author information

1
Departments of Biological Chemistry and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21505.

Abstract

Neurofilaments make up the major intermediate filament system in mature neurons. Recent studies demonstrate that neurofilaments in vivo are obligate heteropolymers and are required for proper radial growth of axons. Furthermore, forced over-expression of neurofilament subunits in transgenic mice shows that abnormal accumulation and assembly of neurofilaments, similar to that commonly found in human motor neuron disease can directly cause motor neuron dysfunction.

PMID:
7513179
DOI:
10.1016/0955-0674(94)90113-9
[Indexed for MEDLINE]

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