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Trends Neurosci. 1994 Jan;17(1):9-13.

Long-term regulation of short-term transmitter release properties: retrograde signaling and synaptic development.

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Neuroscience and Behavior Program, Morrill Science Center (Biology), University of Massachusetts, Amherst 01003.


The dynamics of presynaptic transmitter release are often matched to the physiological properties and functions of the postsynaptic cell. In organisms ranging from cats to crickets, evidence suggests that retrograde signaling is essential for matching these presynaptic release properties to individual postsynaptic partners. Retrograde interactions appear to control the development of presynaptic, short-term facilitation and homosynaptic depression through local, retrograde signaling at the synapse.

[Indexed for MEDLINE]

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