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Trends Neurosci. 1994 Jan;17(1):22-30.

Messenger plasticity in primary sensory neurons following axotomy and its functional implications.

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Dept of Neuroscience, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.


Following peripheral axotomy, long-lasting changes in the expression of neuropeptides and their receptors in primary sensory neurons are observed. These changes involve the downregulation of the excitatory peptides substance P and calcitonin gene-related peptide and the upregulation of the inhibitory peptides neuropeptide tyrosine and galanin, resulting in a reduction of transmission in the dorsal horn. The changes observed are thought to represent adaptive responses to limit the consequences of peripheral nerve damage to the organism as a whole and to promote survival and recovery of the individual neuron.

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