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J Gen Virol. 1994 Jan;75 ( Pt 1):157-64.

Immune response to human papillomavirus type 16 E6 gene in a live vaccinia vector.

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1
Department of Biology, University College London, U.K.

Abstract

Immunization of mice with a recombinant vaccinia virus expressing the human papillomavirus type 16 (HPV-16) E6 gene elicits specific antibody, proliferative and cytotoxic T lymphocyte responses. T and B cell epitopes were mapped by using synthetic peptides. This study provides the background to future investigation aimed at developing prophylactic and therapeutic vaccines against HPV-16 infection and cervical cancer.

PMID:
7509369
DOI:
10.1099/0022-1317-75-1-157
[Indexed for MEDLINE]
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