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J Immunol Methods. 1993 Dec 3;166(2):287-91.

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice.

Author information

1
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.

Abstract

We describe a plasmid vector that drives the expression of foreign cDNAs in transgenic mice, according to the dictates of an MHC class II gene promoter. Using this vector, we have often obtained mRNA and protein synthesis with a tissue and cell-type specificity indistinguishable from that of the endogenous MHC class II genes.

PMID:
7507147
DOI:
10.1016/0022-1759(93)90370-m
[Indexed for MEDLINE]

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