Format

Send to

Choose Destination
Immunol Today. 1993 Oct;14(10):483-6.

Costimulation of T cells for tumor immunity.

Author information

1
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121.

Abstract

Tumor specific antigens can be demonstrated on many neoplasms by immunization and challenge experiments; however, these antigens do not normally elicit a sufficiently strong immune response to prevent tumor growth in immunocompetent hosts. Recent studies have demonstrated that efficient activation of T cells requires costimulation of the CD28 receptor via the B7 molecule on antigen-presenting cells. Inadequate costimulation of tumor-reactive T cells may contribute to the fact that antigenic tumors are not normally rejected by the immune system, and weak anti-tumor immune responses may be amplified by upregulation of CD28 triggering.

PMID:
7506034
DOI:
10.1016/0167-5699(93)90262-J
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center