Format

Send to

Choose Destination
See comment in PubMed Commons below
Obstet Gynecol. 1995 Dec;86(6):1031-4.

Clinical research in ancient Babylon: methodologic insights from the book of Daniel.

Author information

1
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA.

Abstract

Around 600 BC, Daniel of Judah conducted what is widely regarded as the earliest recorded clinical trial. His trial compared the health effects of a vegetarian diet with those of a royal Babylonian diet over a 10-day period. The strengths of his study include the use of a contemporaneous control group, use of an independent assessor of outcome, and striking brevity in the published report. Weaknesses include probable selection bias, ascertainment bias, and confounding by divine intervention. Although Daniel probably never achieved tenure, he did get "learning and skill in all letters and wisdom ... and understanding in all visions and dreams" (well before Freud). Despite the trial's dramatic findings, over 4 centuries elapsed before publication of Daniel's results. Daniel apparently perished, then published.

PMID:
7501328
DOI:
10.1016/0029-7844(95)00276-W
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center