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Obstet Gynecol. 1995 Dec;86(6):1021-5.

Amoxicillin or erythromycin for the treatment of antenatal chlamydial infection: a meta-analysis.

Author information

1
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Houston Health Science Center, Houston, USA.

Abstract

OBJECTIVE:

To compare the effectiveness of amoxicillin and erythromycin for the treatment of antenatal Chlamydia trachomatis infection by meta-analysis of available trials involving random assignment of subjects.

DATA SOURCES:

A computer search of English-language abstracts using MEDLINE and the Cochrane Pregnancy and Childbirth Database (medical subject heading terms: pregnancy, chlamydia, erythromycin, amoxicillin, antenatal antibiotics) was supplemented with a review of the bibliographies of the relevant articles generated by the computer search.

METHODS OF STUDY SELECTION:

Five trials were identified, four of which met our inclusion criteria for the meta-analysis.

DATA EXTRACTION AND SYNTHESIS:

Trials to be included in this meta-analysis underwent trial quality evaluation and data abstraction. An estimate of the relative risk (RR) was calculated for the dichotomous outcomes using a fixed-effects model. The pooled RR for the effectiveness of amoxicillin compared with erythromycin was 1.11 (95% confidence interval [CI] 1.05-1.18), and the pooled RR for gastrointestinal side effects of amoxicillin compared with erythromycin was 0.29 (95% CI 0.20-0.42). The pooled RR for gastrointestinal side effects that resulted in discontinuation of therapy of amoxicillin compared with erythromycin was 0.14 (95% CI 0.06-0.36).

CONCLUSION:

The available data suggest that amoxicillin is more effective than erythromycin for the treatment of antenatal C trachomatis infection and has fewer gastrointestinal side effects, leading to better compliance.

PMID:
7501326
DOI:
10.1016/0029-7844(95)00296-4
[Indexed for MEDLINE]

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