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Nature. 1995 Dec 14;378(6558):690-7.

A structural role for hormone in the thyroid hormone receptor.

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1
Graduate Group in Biophysics, University of California at San Francisco 94143-0448, USA.

Abstract

The crystal structure of the rat alpha 1 thyroid hormone receptor ligand-binding domain bound with a thyroid hormone agonist reveals that ligand is completely buried within the domain as part of the hydrophobic core. In addition, the carboxy-terminal activation domain forms an amphipathic helix, with its hydrophobic face constituting part of the hormone binding cavity. These observations suggest a structural role for ligand, in establishing the active conformation of the receptor, that is likely to underlie hormonal regulation of gene expression for the nuclear receptors.

PMID:
7501015
DOI:
10.1038/378690a0
[Indexed for MEDLINE]
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