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Dent Mater. 1994 Sep;10(5):304-13.

Biological and clinical investigations of a glass ionomer base material.

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Department of Operative Dentistry and Periodontology, University of Regensburg, Germany.



The purpose of this study was to investigate the biological properties of a new glass ionomer base material containing strontium glass.


The glass ionomer base material (Base Line, De Trey Dentsply) was tested for cytotoxicity using a standard agar diffusion test, for its effect upon the pulp in subhuman primates, and in a clinical study as base beneath both composite fillings and amalgam fillings.


The material showed a cytotoxicity pattern similar to reference materials, a zinc phosphate cement and a reference glass ionomer base material, which are used successfully in clinical applications. With the pulp/dentin usage test in subhuman primates, there were no statistically significant differences between the experimental glass ionomer base material and the negative control group if bacterial contamination of the cavity floor or direct contact with the pulp was avoided. The results of the clinical study also indicated no pulp damage after one year.


The experimental glass ionomer base material proved to be acceptable both biologically and clinically.

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