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Exp Neurol. 1995 Dec;136(2):199-204.

Decrease of neurotrophin-3 mRNA in adult rat hippocampus after pilocarpine seizures.

Author information

1
Department of Neuroscience, Histology, Karolinska Institute, Stockholm, Sweden.

Abstract

Neurotrophins such as NT-3 are subject to complex regulation during epileptic seizures. Pilocarpine at a dose of 250 mg/kg induced either limbic seizures (LS) or limbic motor status epilepticus (LMSE) in adult rats. In situ hybridization signals for NT-3 mRNA declined moderately after LS and were nearly lost in LMSE at 3-4 h. Loss of NT-3 mRNA expression does not correlate with cell death and may reflect a functional down-regulation in certain hippocampal neurons.

PMID:
7498409
DOI:
10.1006/exnr.1995.1096
[Indexed for MEDLINE]

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