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Chest. 1995 Dec;108(6):1754-6.

Effect of prostacyclin on microvascular pressures in a patient with pulmonary veno-occlusive disease.

Author information

1
Louisiana State University Medical School, New Orleans, USA.

Abstract

Continuous-infusion prostacyclin improves symptom scores and decreases mortality in patients with primary pulmonary hypertension, but use of prostacyclin in patients with pulmonary veno-occlusive disease may precipitate pulmonary edema. A patient with pulmonary veno-occlusive disease received a graduated intravenous infusion of prostacyclin and pulmonary capillary pressures were calculated during prostacyclin dose ranging. Calculated capillary pressure increased with low-dose prostacyclin (< or = 6 ng/kg/min) but decreased with higher doses. These data suggest that the post-capillary pulmonary venules in our patient had reversible vasomotor tone, but required a higher dose of prostacyclin to vasodilate than did the precapillary arterioles.

PMID:
7497799
DOI:
10.1378/chest.108.6.1754
[Indexed for MEDLINE]

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