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Eur J Gastroenterol Hepatol. 1995 Aug;7(8):803-6.

Undefined malabsorption syndrome with villous atrophy successfully reversed by treatment with cyclosporine.

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Department of Gastroenterology and Hepatology, Nijmegen University Hospital, The Netherlands.


A 47-year-old man with a flat jejunal mucosa complicated by malabsorption, diarrhoea and lymphocytic colitis is presented. There was no response to gluten withdrawal alone, combination of a gluten-free diet and prednisone therapy, or total parenteral nutrition. Complete clinical remission was only achieved after simultaneous treatment with cyclosporine and a gluten-free diet. Rechallenge with a gluten-containing diet while cyclosporine treatment continued resulted in a relapse of diarrhoea and malabsorption. We conclude that cyclosporine may be an effective agent for the treatment of undefined, refractory forms of malabsorption.

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