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Aliment Pharmacol Ther. 1995;9 Suppl 1:27-30.

The role of Helicobacter pylori in gastritis and its progression to peptic ulcer disease.

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Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232-2605, USA.


Helicobacter pylori infection is now recognized as the major cause of chronic gastritis throughout the world. A fraction of infected persons develop peptic ulcer disease or gastric cancer, accounting for its clinical significance. The pathophysiology of this infection can be better understood by considering five central concepts--heterogeneity of strains, persistence of infection, immunological down-regulation, physiological consequences and variability in outcome. Microbial, host and environmental factors must each contribute to the outcome variation.

[Indexed for MEDLINE]

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