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Curr Opin Cell Biol. 1995 Aug;7(4):573-80.

The emergence of clathrin-independent pinocytic pathways.

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Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA.


Receptor-mediated endocytosis via clathrin-coated vesicles is by far the best characterized example of pinocytosis. It has been suggested that clathrin-coated vesicles mediate all pinocytosis in mammalian cells. This is still a matter of debate, however, and recent results provide strong evidence for 'clathrin-independent' pinocytic pathways. The selective regulation of these alternate endocytic pathways and the identification of receptors targeted to them provide new tools for the functional and mechanistic characterization of clathrin-independent pinocytosis.

[Indexed for MEDLINE]

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