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Curr Opin Cell Biol. 1995 Aug;7(4):523-9.

Quality control in the secretory pathway.

Author information

1
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06511, USA.

Abstract

Whereas newly synthesized proteins that have acquired a properly folded and assembled structure are transported from the endoplasmic reticulum to their final destinations, incompletely folded and assembled proteins are, as a rule, retained and eventually degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called 'quality control', have been illuminated by recent studies.

PMID:
7495572
DOI:
10.1016/0955-0674(95)80009-3
[Indexed for MEDLINE]

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