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Immunol Today. 1995 Nov;16(11):539-46.

Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes.

Author information

1
Louis Jeantet Laboratory of Molecular Genetics, Dept of Genetics and Microbiology, University of Geneva Medical School, Switzerland.

Abstract

The complex pattern of expression of major histocompatibility complex (MHC) class II molecules plays an essential role in the control of the immune response. Our understanding of the molecular mechanisms controlling this expression has benefited greatly from the identification of the regulatory factors defective in two forms of a hereditary disease of MHC class II regulation: bare lymphocyte syndrome. This has also provided new tools for the experimental modulation of MHC class II expression.

PMID:
7495492
DOI:
10.1016/0167-5699(95)80048-4
[Indexed for MEDLINE]

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