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Brain Res Mol Brain Res. 1995 Aug;32(1):176-80.

Effects of chronic social stress on tyrosine hydroxylase mRNA and protein levels.

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  • 1Rockefeller University, New York, NY 10021, USA.


Males housed in mixed sex groups quickly form dominance hierarchies; subordinates can be further subdivided into stress responsive subordinates (SRS) and non-responsive subordinates (NRS) based on corticosterone responses to a novel stressor. Tyrosine hydroxylase (TH) mRNA levels measured with in situ hybridization were elevated in locus coeruleus (LC) of NRS compared to singly or pair-housed controls; NRS also had higher TH levels than dominants. TH protein levels determined by immunoautoradiography were also higher in LC of NRS and SRS versus pair-housed controls.

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