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Free Radic Res. 1995 Oct;23(4):365-70.

The free radical scavenger, alpha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils.

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1
Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 USA.

Erratum in

  • Free Radic Res 1995 Dec;23(6):629.

Abstract

alpha-Lipoic acid (thioctic acid) was tested for its neuroprotective activity in a Mongolian gerbil model of forebrain ischemia/reperfusion. Adult gerbils were treated for 7 days with two intraperitoneal injections per day of alpha-lipoic acid (20 mg/kg), vehicle or saline and on the 7th day the animals were subjected to 5 min of forebrain ischemia. Ischemic injury was assessed by monitoring the increases in locomotor activity and from the extent of damage to the CA1 hippocampal pyramidal cell layer after 5 days of recovery. By both criteria, alpha-lipoic acid was neuroprotective against ischemia/reperfusion evoked cerebral injury.

PMID:
7493042
[Indexed for MEDLINE]

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